Ok guys, it's time to pick up where we left off! We are heading back to the topic of diabetes! Let me just refresh your memory. Based on statistics released this January, 25.8 million children and adults in the United States, roughly 8.3% of the population have diabetes.There is still a whopping 7 million people undiagnosed and 79 million prediabetics in the US. Today, let's discuss the sulfonylureas, a class of oral hypoglycemics that are widely used for diabetes mellitus (type 2) management. In the following paragraph, I'm going to enlighten you on the mechanism of action, side effect profile, clinical effects and additional clinical pearls of this particular class of medication! Let's begin, shall we?
First off, understand that the class sulfonylurea is broken down into three generations, first, second, and third generation sulfonylureas. Please find a list below....this list is not inclusive of EVERY sulfonylurea on the market!
- Orinase (tolbutamide)
- Tolinase (tolazamide)
- Diabinese (chlorpropamide)
- Glucotrol & Glucotrol XL (glipizide)
- Micronase, Diabeta, Glynase (glyburide & micronized glyburide)
- Amaryl (glimepiride)
1. May be taken with or without food however, Glucotrol (immediate release) should be taken prior to meals.
2. Use caution and/or seek guidance from a healthcare professional if you have allergies to sulfa drugs.
3. Be sure to maintain normal eating habits with oral hypoglycemic agents on board...helps minimize chances of hypoglycemia (low blood sugar)
4. Always maintain a diabetic diet...low carbs and sugar
5. Be sure to ask questions about any medications that you are taking after all....it is your life and your health!